top of page
  • Writer's pictureDr. Karenne Fru, MD, PhD, Reproductive Endocrinologist

A Beginner's Guide to Egg Donation

Donating eggs involves a woman providing her eggs to another person with the goal of achieving pregnancy. Egg donation can offer a solution for women facing fertility challenges related to their ovaries or age, enabling them to successfully carry a baby.

The process of egg donation is relatively straightforward. Once a donor has been approved, she receives hormone injections to stimulate her ovaries. After a period of two to four weeks, when the eggs are ready, a minor medical procedure is performed to retrieve them from the donor's ovaries.

To qualify as a donor, women must meet certain eligibility criteria. These often include being between the ages of 21 and 31, having a body mass index (BMI) between 19 and 29, and having regular menstrual periods. Additionally, women should not be using any form of birth control implants.

How many times can you donate eggs?

Even when meeting these eligibility requirements, there are limitations on the number of times a woman can donate eggs. This is primarily due to the potential for long-term health effects. While the egg retrieval procedure is generally safe, there is always a risk of complications.

The American Society for Reproductive Medicine (ASRM) has set the maximum number of egg donation cycles a donor can undergo at six. This limit applies regardless of the clinic being used. It's important to note that typically multiple eggs are provided per procedure, and the ASRM restriction applies specifically to the retrieval process. The main concern is maintaining genetic diversity, as consanguinity, or genetic relatedness, plays a significant role in overall health.

Another aspect to consider is a woman's eligibility status, which is typically influenced by reaching the age limit of 31 years. Any changes in a donor's health can affect their eligibility.

How often can you donate eggs?

Regarding the frequency of egg donation, the ASRM recommends a minimum interval of 60 days between donations. This downtime allows the donor's body to fully recover from the physical toll of the procedures. While reproductive health is one factor to consider, overall health takes precedence.

It's worth noting that fertility clinics may have their own guidelines that dictate the interval between donations. It is not uncommon for clinics to require longer waiting periods, some even calling for 90 days. If a clinic does not enforce a 60-day interval, donors should listen to their bodies and follow their physician's advice.

Are there limits on egg donation?

The presence of limits on egg donation primarily stems from the physical toll the procedure takes on the donor's body. Although it is a safe process, it is still invasive. Additionally, the hormone treatment involved can lead to rare side effects that impact the donor's well-being.

Potential adverse reactions to the procedure include infections, which can cause pain, bleeding, inflammation, and long-term damage. Another rare situation is ovarian torsion, in which the ovarian stimulation increases the likelihood of the ovary spinning, resulting in restricted blood supply and necessitating corrective surgery. Ovarian Hyperstimulation Syndrome (OHSS) is another concern, wherein the hormones used to stimulate the ovaries can cause pain and nausea. Bed rest and pain relievers are often sufficient, but in rare cases, hospitalization may be required.

Benefits of multiple egg donations

Considering multiple egg donations is an option worth deliberating. Many couples around the world require assistance in conceiving a child, and obtaining eggs is not as simple as acquiring sperm. Women willing to donate their eggs are relatively uncommon. Therefore, the more eggs a donor can provide, the greater the impact on people needing them, and there are increased chances for genetic siblings among couples. This act of donation can be a rewarding and fulfilling experience for many.

However, potential donors should consider certain factors before deciding to become an egg donor. Future family plans should be taken into account, as rare long-term side effects from the egg donation procedure may affect a donor's ability to conceive later on. The emotional aspect of knowing that one's eggs will be used by another woman can cause turmoil, and motivations for donation should be carefully contemplated. These concerns are typically addressed through a psychosocial evaluation as part of the screening process.

It is important to note that financial compensation is offered for egg donations, with the amount varying depending on the clinic and other factors. However, it is crucial to understand that compensation is not immediate and can take a month or longer to receive after the retrieval. Making an egg donation should not be viewed as a solution for immediate financial distress.


While it is undeniable that egg donation has positively transformed the lives of many couples, it is crucial to consider your own future and happiness when contemplating this decision. What are your motivations for pursuing egg donation? Are your reasons driven by altruism, and are you prepared to confront potential short-term or long-term side effects?

Like any major life decision, it is imperative that you thoroughly grasp the advantages and disadvantages associated with egg donation before fully committing. While your generosity could potentially benefit numerous couples, it is paramount to ensure that this choice aligns with your own circumstances and aspirations.


bottom of page